Arizona is made for road trips, but this route adds a refreshing twist. Over several days, you will travel from rushing waterfalls and rugged desert scenery to welcoming wineries serving bottles crafted from locally grown grapes.
The journey covers nearly 850 miles, with about 15.5 hours of total driving time. Rather than rushing through it, spread the route across a few days so you can linger at the waterfalls, enjoy relaxed wine tastings, and take in the changing landscapes along the way.
Several Best Western hotels sit close to the route, giving you convenient places to rest between stops. After a day of hiking, sightseeing, and sampling Arizona wines, you can recharge before setting out for the next stretch.
Pack comfortable shoes, bring plenty of water, and leave room in the trunk for a bottle or two. This Arizona road trip blends outdoor adventure, local flavor, and memorable overnight stops into one remarkable getaway.
1. Grand Falls, Flagstaff: A Seasonal Cascade Worth Timing Right
Grand Falls makes a dramatic opening stop on this Arizona waterfall road trip. Dropping more than 180 feet along the Little Colorado River, the broad cascade tumbles over dark volcanic rock and creates one of the state’s most striking natural scenes.
Water levels depend heavily on melting snow from the White Mountains and seasonal rainfall. Spring runoff and the summer monsoon period often offer the strongest flow, while the falls may appear nearly dry during other parts of the year.
You can admire the waterfall without completing a long hike. A nearby overlook provides sweeping views, while a short path leading closer to the river offers another angle for travelers who want to spend extra time at the site.
2. Water Wheel Falls, Payson: A Refreshing Creekside Stop
Water Wheel Falls may be modest in size, yet its rocky setting and cool swimming hole make it a rewarding stop near Payson. The waterfall takes its name from an old water wheel found beside the trail, adding an interesting landmark to the walk.
Reaching the falls requires a one-mile hike across uneven and occasionally rocky ground. The path remains manageable for many visitors and follows a scenic creek corridor filled with boulders, shaded sections, and flowing water.
Pack water shoes and a swimsuit during warmer months. The shallow pool beneath the cascade offers a refreshing break from the Arizona heat, though water levels and currents can change after heavy rainfall.
After visiting two waterfalls in one day, spend the night at the Best Western Inn of Payson. You can also continue farther along the route and stay at the Best Western Copper Hills Inn before beginning the next section of the trip.
3. Carlson Creek Vineyard, Willcox: High-Elevation Wines and Open-Air Tastings
Carlson Creek Vineyard brings a flavorful pause to this Arizona road trip. This family-owned winery sits in southeastern Arizona at roughly 4,200 feet above sea level, where the cooler climate helps grapes develop deeper color, thicker skins, and bold character.
Settle onto the outdoor patio and sample a selection of locally produced wines while taking in the surrounding vineyard views. Guided tours may also be available for travelers interested in learning how the grapes are grown, harvested, and turned into each bottle.
The winery regularly hosts classes, tastings, and seasonal events, so checking the calendar before your visit may add something extra to the stop. Afterward, continue to Sierra Vista and spend the night at the Best Western Plus Sun Canyon, a comfortable place to unwind before the next leg of the drive.
4. Callaghan Vineyards, Elgin: Award-Winning Arizona Wines and a Relaxed Picnic Stop
Callaghan Vineyards is an essential addition to any winery route through southern Arizona. Known for producing highly regarded wines, this Elgin vineyard has earned national attention, with its bottles reportedly served at several White House dinners.
Step inside the tasting room to sample the selections that helped build the winery’s reputation. The welcoming atmosphere makes it easy to slow down, compare different pours, and learn more about Arizona’s growing wine culture.
Bring a picnic lunch and enjoy a restful break before returning to the road. Good food, local wine, and the surrounding countryside make this stop a pleasant contrast to the waterfall adventures earlier in the journey.
5. Charron Vineyards, Vail: Desert Scenery and Creative Wine Flavors
Charron Vineyards sits near Vail, just outside Tucson, where wide desert views create a striking backdrop for this winery stop. Its peaceful patio and rugged surroundings offer a pleasant place to pause during the road trip.
Adult visitors can choose from more than 16 wine options, ranging from familiar favorites to less expected varieties. The winery is especially known for its dry wines and white Merlot, while its chilled wine slushies remain a popular seasonal choice during Arizona’s warmer months.
After leaving the vineyard, continue to the Best Western Tucson International Airport Hotel and Suites. A comfortable overnight stay provides time to rest before setting out for the final stretch of this Arizona adventure.
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